產品中心
相關產品
標記一抗
英文名稱Anti-A4GNT/FITC
中文名稱:FITC標記的α1,4-N-乙酰葡糖胺轉移酶α4Gn-T抗體
別 名4-N-acetylglucosaminyltransferase; A4GCT_HUMAN; A4GNT; Alpha 1 4 N acetylglucosaminyltransferase; Alpha-1; Alpha4GnT; EC 2.4.1.; MGC149493.
規(guī)格:100ul
說 明 書100ul
研究領域腫瘤 細胞生物 信號轉導
抗體來源Rabbit
克隆類型Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
產品應用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
細胞定位細胞膜
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human A4GNT (131-180aa)
亞 型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
產品介紹background:
Alpha 1,4-N-acetylflucosaminyltransferase (Alpha4Gn-T) mediates the biosynthesis of mucin type glycoprotein (O-glycan). Alpha4Gn-T acts as the key enzyme for the formation of the unique glycan GlcNAcalpha1-4Galbeta1-R, and most efficiently transfers N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Alpha4Gn-T is a single-pass type II membrane protein associated with the Golgi apparatus and contains the conserved DXD motif involved in catalytic activity. It is expressed in stomach and pancreas, as well as in gastric cancer cells. Alpha4Gn-T is not expressed in peripheral blood cells, making it a useful biomarker for pancreatic cancer. Alpha4Gn-T and Mucin 6 expression is upregulated in the gastric mucosa of H.pylori infected patients, which suggest the involvement of ?Gn-T in defense against H. pylori infection
Function:
Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans.
Subcellular Location:
Golgi apparatus membrane.
Tissue Specificity:
Detected in stomach and pancreas.
Similarity:
Belongs to the glycosyltransferase 32 family.
Database links:
UniProtKB/Swiss-Prot: Q9UNA3.1
中文名稱:FITC標記的α1,4-N-乙酰葡糖胺轉移酶α4Gn-T抗體
別 名4-N-acetylglucosaminyltransferase; A4GCT_HUMAN; A4GNT; Alpha 1 4 N acetylglucosaminyltransferase; Alpha-1; Alpha4GnT; EC 2.4.1.; MGC149493.
詳細介紹：
規(guī)格:100ul
說 明 書100ul
研究領域腫瘤 細胞生物 信號轉導
抗體來源Rabbit
克隆類型Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
產品應用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
細胞定位細胞膜
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human A4GNT (131-180aa)
亞 型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
相關資料：
產品介紹background:
Alpha 1,4-N-acetylflucosaminyltransferase (Alpha4Gn-T) mediates the biosynthesis of mucin type glycoprotein (O-glycan). Alpha4Gn-T acts as the key enzyme for the formation of the unique glycan GlcNAcalpha1-4Galbeta1-R, and most efficiently transfers N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Alpha4Gn-T is a single-pass type II membrane protein associated with the Golgi apparatus and contains the conserved DXD motif involved in catalytic activity. It is expressed in stomach and pancreas, as well as in gastric cancer cells. Alpha4Gn-T is not expressed in peripheral blood cells, making it a useful biomarker for pancreatic cancer. Alpha4Gn-T and Mucin 6 expression is upregulated in the gastric mucosa of H.pylori infected patients, which suggest the involvement of ?Gn-T in defense against H. pylori infection
Function:
Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans.
Subcellular Location:
Golgi apparatus membrane.
Tissue Specificity:
Detected in stomach and pancreas.
Similarity:
Belongs to the glycosyltransferase 32 family.
Database links:
UniProtKB/Swiss-Prot: Q9UNA3.1
- 上一條：FITC標記的A2LD1蛋白抗體
- 下一條：FITC標記的脂肪酰輔酶A家族成員1抗體
